Neukine-filgrastim
Neukine contains filgrastim and belongs to a class of medications called colony-stimulating factors.

Indication
Neukine is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing bone marrow transplants that will cause low white blood cell counts, and in people who have severe chronic neutropenia (a condition in which there are a low number of neutrophils in the blood). This will decrease the risk of infection in cancer patients who are receiving chemotherapy. Nufil is also used to decrease the risk of infection in patients with weakened immune systems due to other causes.

Neukine is also used to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the body and then returned to the body following chemotherapy).

Mechanism of action

Neukine works by stimulating the production of neutrophils (a type of white blood cells) by the bone marrow.

Supplied as
Neukine is available as 300 microgram in a pre-filled syringe (pfs).

Dosage
The dosage of neukine varies according to the disease of the patient.

Precautions & Warnings
Neukine should not be taken without consulting your doctor if you are taking lithium or undergoing chemotherapy, growth factor therapy, or radiation therapy; if you have leukemia, other blood disorders (eg, myelodysplastic syndrome), an infection of the blood or tissue, or sickle cell disease. Also, do not take aspirin or products containing aspirin without consulting your doctor.

Do not take neukine if you are allergic to it or to any ingredient in neukine, or to escherichia coli (e. Coli)-derived proteins.

Do not take neukine without consulting your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with neukine. It is not known whether neukine passes into breast milk. Do not take neukine without consulting your doctor, if you are breast feeding a baby.

Side effects
The side effects associated with neukine are severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue); chest pain; diarrhea; dizziness; fast or irregular heartbeat; fever; lump, swelling,mouth sores; redness, severe weakness; shortness of breath; shoulder pain; sore throat; sudden increased sweating; wheezing, bone or muscle pain or ache; cough; headache; nausea; skeletal/muscle pain & vomiting etc.

Note: Neukine is a prescription drug and should be used under proper medical guidance and advice.

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